FRACTIONAL CO2 TECHNOLOGY- INTIMA

CO2RE Intima leverages the CO2RE platform
CO2RE Intima Backgrounder

Interest in women’s intimate wellness, including treating vulvar disease (inflammatory, ulcerative, and blistering disorders, as well as pigmentary changes and atrophy) and modifying the cosmetic appearance of the vulva (sagging skin, pigmentation, texture), is steadily increasing.1,2 Treatment for vulvar disease is intended to address the associated symptoms, including: itching; burning; painful sexual intercourse; thickened or thin skin on the vulva, and stinging or irritation.

1. Cihantimur B, Herold C. Genital beautification: a concept that offers more than reduction of the labia minora. Aesthetic Plast Surg. 2013;37(6):1128-33. 
2. Schwartz RA. Benign vulvar lesions. At: http:// emedicine.medscape.com/article/264648- overview. Accessed Nov. 11, 2015.

Mechanisms of Action of the CO2RE Fractional CO2 Laser on Vaginal and Vulvar Tissue and Effects on Female Genitourinary and Sexual Health

Changes in genitourinary anatomy and physiology can adversely affect female sexual health and quality of life over a woman’s lifetime. Common medical conditions due to childbirth or age-related changes include Vaginal Relaxation Syndrome (VRS), Stress Urinary Incontinence (SUI), the Genitourinary Syndrome of Menopause and Vulvar and Vaginal Atrophy (VVA). Vaginal laxity, mild to moderate SUI and symptoms of increased dryness, itching, burning and dyspareunia result in discomfort and problems with intimacy and sexual satisfaction for many women.1,2

 

1. Palacios S, et al. Update on management of genitourinary syndrome of menopause: A practical guide. Maturitas (2015), http://dx.doi.org/10.1016/j.maturitas.2015.07.020 
2. Pauls RN, et al. Vaginal laxity: a poorly understood quality of life problem; a survey of physician members of the International Urogynecological Association (IUGA). Int Urogynecol J. 2012. DOI 10.1007/ s00192-012-1757-4.

FRACTIONAL CO2 TECHNOLOGY- INTIMA GLOSSARY

Chromophore
10939
5
Collagen
4678
36
Condyloma
10940
13
Denature
10941
4
Dyspareunia
10942
8
Dysuria
10943
1
Elastin
4694
41
Energy fluence
4698
232
Fractional skin resurfacing
10944
18
Genital beautification
10945
12
Genital rejuvenation (also referred to as vaginal rejuvenation)
10946
15
Genital warts (also referred to as condylomata acuminate)
10947
5
Introitus
10948
5
Labia
10949
2
Labiaplasty
10950
8
Laser-assisted vaginoplasty
10951
15
Menopause
10952
1
Neocollagenesis
4717
45
Neoelastogenesis
8123
23
Pulse
4736
156
Selective photothermolysis
6037
132
Stress urinary incontinence (SUI)
10953
14
Vaginal mucosa
10954
4
Vaginal rejuvenation (also referred to as genital rejuvenation)
10955
11
Vaginal relaxation syndrome (VRS)
10956
6
Vaginal vault
10957
1
Vaginal vestibule
10958
9
Vulva
10959
6
Vulvar disease
10960
2
Vulvar dystrophy
10961
4
Chromophore
Endogenous light-absorbing chemicals, which absorb light of a specific wavelength.
Collagen
As the most abundant protein in the human body, it is regarded as the substance that holds the whole body together and can be found in the bones, muscles, skin and tendons. Collagen, elastin and hyaluronic acid form the “building blocks” of the skin.
Condyloma
An infection of the genitals. There are two subtypes: Condyloma acuminata, or genital warts, caused by human papilloma virus subtypes 6, 11, and others or Condylomata lata, white lesions associated with secondary syphilis.
Denature
To destroy the characteristic properties of a protein (like collagen or elastin) by heat. Proteins can be completely or partially denatured, as a result of various degrees of heating.
Dyspareunia
Painful sexual intercourse due to medical or psychological causes.
Dysuria
Painful or difficult urination.
Elastin
A protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched.
Energy fluence
The energy contained within light is expressed in Joules (J). The energy fluence determines the amount of laser energy delivered in a single pulse and is expressed in Joules/cm2.
Fractional skin resurfacing
An ablation and coagulation process by which thermal wounds are created in a nonhomogeneous fractional form in tissue.
Genital beautification
Aesthetic female genital surgery techniques to modify the appearance of the vagina and its structures. Techniques include: labia minora reduction, labia majora augmentation by autologous fat transplantation, labial brightening by laser, mons pubis (rounded mass of fatty tissue lying over joint of pubis bones) reduction by liposuction, and vaginal tightening.
Genital rejuvenation (also referred to as vaginal rejuvenation)
Surgical procedures to help tighten and support the vagina and its structures. Laser resurfacing can also be used to modify the cosmetic appearance of the vulva (sagging skin, pigmentation, texture).
Genital warts (also referred to as condylomata acuminate)
Skin lesions of the genital, perineal and anal areas and one of the most common types of sexually transmitted infections.
Introitus
Entrance to the vaginal canal.
Labia
Lip-like structures of the female genitalia, consisting mostly of skin and adipose (fatty) tissue. They form the major externally visible portions of the vulva. In humans, there are two pairs of labia: the labia majora (or the outer labia) are larger and fattier, while the labia minora are folds of skin between the outer labia. The labia surround and protect the clitoris and the openings of the vagina and the urethra.
Labiaplasty
A plastic surgery procedure for altering the appearance of the labia minora and the labia majora.
Laser-assisted vaginoplasty
Treatment to ablate and coagulate vaginal tissue by using wavelengths having high water absorption, such as the CO2 laser (10,600 nm). A wound response is initiated due to the heating and results in tissue remodeling with neocollagenesis and neoelastogenesis in atrophic skin.
Menopause
The time in most women's lives when menstrual periods stop permanently, and the woman is no longer able to have children. Menopause typically occurs between 45 and 55 years of age. During menopause transition (perimenopause), hormone levels and menstrual cycle length begin to fluctuate. Symptoms that may appear during menopause and continue through postmenopause include: painful intercourse, vaginal dryness and loss of elasticity, and atrophic vaginitis (thinning of the membranes of the vulva, the vagina, the cervix, and also the outer urinary tract, along with considerable shrinking and loss in elasticity of all of the outer and inner genital areas).
Neocollagenesis
Creation and inducement of new collagen within the skin. Only with Profound, the real-time temperature under the skin can be monitored and the optimal thermal profile (temperature and time) be created to partially denature collagen in the dermis (layer under the epidermis). Partially denatured (destroyed) collagen heals faster than completely denatured collagen. During the healing process, new collagen is formed and creates visibly smoother skin with improved skin laxity.
Neoelastogenesis
Creation and inducement of new elastin within connective tissue, similar to the process of neocollagenesis.
Pulse
The brief span of time for which, the focused and scanned laser beam interacts with a given point on the skin (in seconds, milliseconds, nanoseconds).
Selective photothermolysis
A concept used to localize thermal injury to a specific target based on its absorption characteristics, the wavelength of light used, the duration of the pulse, and the amount of energy delivered.
Stress urinary incontinence (SUI)
Unintentional loss of urine that occurs when physical movement or activity — such as coughing, sneezing, running or heavy lifting — puts pressure on the bladder.
Vaginal mucosa
The first layer of the vagina that is made up of a mucus membrane of non-keratinized stratified squamous (flattened) epithelium (epithelial cells) with an underlying lamina propria (thin layer of loose connective tissue). The vaginal mucosa is similar to the lining of the mouth. However, unlike the smooth surface of the mouth lining, the vaginal mucosa has many folds or wrinkles.
Vaginal rejuvenation (also referred to as genital rejuvenation)
Usually combines vaginoplasty (“tightening” of the vagina) and/or labiaplasty or vulvaplasty (reshaping of the vulva or labia, the outer and inner lips of the vagina). Laser resurfacing can also be used to modify the cosmetic appearance of the vulva (sagging skin, pigmentation, texture).
Vaginal relaxation syndrome (VRS)
An early form of vaginal prolapse in which vaginal tissue loses elasticity and tone.
Vaginal vault
The expanded region of the vaginal canal at the internal end of the vagina. The vaginal vault may prolapse after a hysterectomy, as there is no uterus supporting the interior end of the vagina.
Vaginal vestibule
Opening of the vagina where the vulva (area of the skin on the outside) meets with the vagina.
Vulva
The outer part of the female genitals. The vulva includes the opening of the vagina (sometimes called the vestibule), the labia majora (outer lips), the labia minora (inner lips), and the clitoris.
Vulvar disease
Can include inflammatory, ulcerative, and blistering disorders, as well as pigmentary changes and atrophy to the vulva.
Vulvar dystrophy
Growth of abnormal skin on the vulva. The skin can be too thin, as with lichen sclerosus, or too thick, as with squamous hyperplasia. Sometimes there can be a mixture of both. Symptoms include: itching; burning; painful sexual intercourse; thickened or thin skin on the vulva, and stinging or irritation.
FRACTIONAL CO2 TECHNOLOGY- INTIMA - CLINICAL PAPERS
02.12.2016
CO2RE Intima | The Aesthetic Guide Clinical Rountable
24.07.2016
A Clinical Study to Evaluate CO2RE Intima Fractional CO2 Laser for Treatment of the Symptoms of Vulvovaginal Atrophy and Vaginal Rejuvenation in Premenopausal Women*
FRACTIONAL CO2 TECHNOLOGY- INTIMA RESULTS

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